In two sentences: Every optional wager at a blackjack table carries a higher house edge than the base game, usually several times higher. They exist because they are profitable for the operator, not because they help you.
Insurance. Offered when the dealer shows an ace, paying 2:1 for a dealer blackjack. Because roughly 30.8% of unseen cards are 10-valued in a fresh multi-deck shoe, the bet loses money at a rate above 7% of the insurance stake. It is a negative-expectation wager for any player who is not tracking the composition of the shoe, which, online, means everybody.
Perfect Pairs. Pays when your first two cards form a pair. A typical paytable: Perfect Pair 25:1, Coloured Pair 12:1, Mixed Pair 6:1. Published house-edge ranges run from about 2.7% to 11%, depending on the paytable and deck count.
21+3. Combines your two cards with the dealer's upcard as a three-card poker hand. Typical paytable: suited trips 100:1, straight flush 40:1, three of a kind 30:1, straight 10:1, flush 5:1. Published house-edge ranges run from about 3.2% to 13.8%.
Blackjack Switch. You play two hands and may swap the second card between them once. The price for that advantage: blackjack pays 1:1, and a dealer 22 pushes against any non-busted player hand. Both rules are large enough to cancel out the swap entirely if you play the base game carelessly.
Bottom line: with a base game near 0.5%, bolting on a 3% to 14% side bet multiplies your expected loss rate per hand. If you want variance, take it in stake size, not in paytable structure.